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Article

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2020

Falck Joanne, Bruns Christine, Hoffmann-Conaway Sheila, Straub Isabelle, Plautz Erik J, Orlando Marta, Munawar Humaira, Rivalan Marion, Winter York, Izsvák Zsuzsanna, Schmitz Dietmar, Hamra F Kent, Hallermann Stefan, Garner Craig Curtis, Ackermann Frauke

Abstract excerpt

Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypoplasia type 3 (PCH3). We have characterized recently generated Piccolo KO (Pclogt/gt ) rats. Analysis of rats of both sexes revealed a dramatic reduction in brain size compared...

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Identifiers

PMID: 32122952
DOI: 10.1523/JNEUROSCI.2316-19.2020
PMCID: PMC7117892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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