Article
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.
The Journal of cell biology - 4 Jul 2005
Matsushita Kenji, Morrell Craig N, Mason Rebecca J A, Yamakuchi Munekazu, Khanday Firdous A, Irani Kaikobad, Lowenstein Charles J
Abstract excerpt
Although an excess of reactive oxygen species (ROS) can damage the vasculature, low concentrations of ROS mediate intracellular signal transduction pathways. We hypothesized that hydrogen peroxide plays a beneficial role in the vasculature by inhibiting endothelial exocytosis that would otherwise induce vascular inflammation and thrombosis. We now show that endogenous H(2)O(2) inhibits thrombin-induced exocytosis...
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