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Article

Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress.

Biochimica et biophysica acta - 1 Oct 2008

Milovanova Tatyana, Chatterjee Shampa, Hawkins Brian J, Hong Nankang, Sorokina Elena M, Debolt Kris, Moore Jonni S, Madesh Muniswamy, Fisher Aron B

Abstract excerpt

Abrupt cessation of flow representing the acute loss of shear stress (simulated ischemia) to flow-adapted pulmonary microvascular endothelial cells (PMVEC) leads to reactive oxygen species (ROS) generation that signals for EC proliferation. We evaluated the role of caveolin-1 on this cellular response with mouse PMVEC that were preconditioned for 72 h to laminar flow at 5 dyn/cm(2) followed by stop of flow...

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Identifiers

PMID: 18573285
DOI: 10.1016/j.bbamcr.2008.05.010
PMCID: PMC2615406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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