Article

Endothelial Trauma Depends on Surface Charge and Extracellular Calcium Levels

2025-07-18

Abstract excerpt

We tested the hypothesis that the ubiquitous store-operated Ca 2+ entry (SOCE) pathway contributes to histone-induced endothelial Ca 2+ events. We also considered an alternate hypothesis: cationic electrostatic interactions between histones and negatively charged phospholipids deform endothelial membranes and thereby allow extracellular Ca 2+ entry. A role for SOCE in histone responses was ruled out by genetic...

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Literature Corpus work: a56ea2b2-96cf-5caf-8c56-1732443bcf98
DOI: 10.1101/2025.07.13.664578

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