Article

Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization

2024-10-01

Abstract excerpt

<h4>Background</h4> Despite antiplatelet therapy, some patients remain at high risk for ischemic events due to medication non-responsiveness or High Residual Platelet Reactivity (HRPR). Our goal was to target an orphan G-Protein-Coupled Receptor (GPCR) on platelets belonging to the olfactory receptor family as a new antithrombotic strategy. <h4>Methods</h4> Using an engineered reporter cell line expressing Olfac...

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Literature Corpus work: 1f28ecf4-4558-52bb-8dbc-d48753dd6a8f
DOI: 10.1101/2024.09.30.615956

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