Article
Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.
Cell - 20 Feb 2004
Liu Limin, Yan Yun, Zeng Ming, Zhang Jian, Hanes Martha A, Ahearn Gregory, McMahon Timothy J, Dickfeld Timm, Marshall Harvey E, Que Loretta G, Stamler Jonathan S
Abstract excerpt
The current perspective of NO biology is formulated predominantly from studies of NO synthesis. The role of S-nitrosothiol (SNO) formation and turnover in governing NO-related bioactivity remains uncertain. We generated mice with a targeted gene deletion of S-nitrosoglutathione reductase (GSNOR), and show that they exhibit substantial increases in whole-cell S-nitrosylation, tissue damage, and mortality following...
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