Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

Abstract excerpt

Small, gaseous molecules, known as gasotransmitters (NO, CO, H 2 S), are produced endogenously in mammalian cells and serve important biological roles. Hydrogen cyanide, traditionally considered a cytotoxic molecule in mammals, serves as an endogenous mediator in several plants and bacterial species. Here we show that low concentrations of cyanide are generated endogenously in mouse liver and human hepatocytes. C...

Topics

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• Carcinogenesis
• Gene Expression Regulation, Enzymologic
• Genetic Predisposition to Disease
• Hydrogen Sulfide
• Models, Genetic
• Promoter Regions, Genetic
• Protein Binding
• Transcription Factors

Identifiers and source

Literature Corpus work

310d40b7-24cf-5bf5-a59b-4e52ab24ecb1

DOI

10.1101/2024.06.03.597146