Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

von Willebrand factor remodeling during exocytosis from vascular endothelial cells.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2013

Mourik M J, Valentijn J A, Voorberg J, Koster A J, Valentijn K M, Eikenboom J

Abstract excerpt

BACKGROUND: In vascular endothelial cells, high molecular weight multimers of von Willebrand factor (VWF) are folded into tubular structures for storage in Weibel-Palade bodies. On stimulation, VWF is secreted and forms strings to induce primary hemostasis. The structural changes composing the transition of stored tubular VWF into secreted unfurled VWF strings are still unresolved even though they are vital for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Exocytosis
Share to Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemostasis

Share to Human Umbilical Vein Endothelial Cells

Share to Platelet Glycoprotein GPIb-IX Complex

Share to Protein Transport

Share to von Willebrand Factor

Source

Identifiers

PMID: 24010820
DOI: 10.1111/jth.12401

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

von Willebrand factor remodeling during exocytosis from vascular endothelial cells.PMID 24010820Read ↗

Functional architecture of Weibel-Palade bodiesSemantic proximity Read ↗

Formation of platelet-binding von Willebrand factor strings on non-endothelial cells.Semantic proximity Read ↗

How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies.Semantic proximity Read ↗

Weibel−Palade bodies at a glanceSemantic proximity Read ↗

Regulated Secretion in Endothelial Cells: Biology and Clinical ImplicationsSemantic proximity Read ↗

Weibel-Palade bodies: a window to von Willebrand disease.Semantic proximity Read ↗

Dispatch and delivery at the ER–Golgi interface: how endothelial cells tune their hemostatic responseSemantic proximity Read ↗

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cellsSemantic proximity Read ↗

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease.Semantic proximity Read ↗

Von Willebrand disease and Weibel-Palade bodies.Semantic proximity Read ↗

Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.Semantic proximity Read ↗

Low oscillatory shear stress regulates Weibel-Palade body size and vWF releaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.