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Article

Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae.

Genetics - 1 Oct 2005

Montpetit Ben, Thorne Ken, Barrett Irene, Andrews Kim, Jadusingh Ravi, Hieter Phil, Measday Vivien

Abstract excerpt

The maintenance of genome stability is a fundamental requirement for normal cell cycle progression. The budding yeast Saccharomyces cerevisiae is an excellent model to study chromosome maintenance due to its well-defined centromere and kinetochore, the region of the chromosome and associated protein complex, respectively, that link chromosomes to microtubules. To identify genes that are linked to chromosome...

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Source

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Identifiers

PMID: 15998715
DOI: 10.1534/genetics.105.045799
PMCID: PMC1456766

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