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Article

Genome-wide genetic analysis of polyploidy in yeast.

Nature - 5 Oct 2006

Storchová Zuzana, Breneman Amanda, Cande Jessica, Dunn Joshua, Burbank Kendra, O'Toole Eileen, Pellman David

Abstract excerpt

Polyploidy, increased sets of chromosomes, occurs during development, cellular stress, disease and evolution. Despite its prevalence, little is known about the physiological alterations that accompany polyploidy. We previously described 'ploidy-specific lethality', where a gene deletion that is not lethal in haploid or diploid budding yeast causes lethality in triploids or tetraploids. Here we report a...

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PMID: 17024086
DOI: 10.1038/nature05178

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