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Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation

2 Apr 2025

Abstract excerpt

Emerging studies hint at the roles of autophagy-related proteins in various cellular processes. To understand if autophagy-related proteins influence genome stability, we sought to examine a cohort of 35 autophagy mutants in Saccharomyces cerevisiae. We observe cells lacking Atg11 show poor mitotic stability of minichromosomes. Single-molecule tracking assays and live cell microscopy reveal that Atg11 molecules...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
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PMID: 40173187
DOI: 10.1371/journal.pbio.3003069

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