Article
A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo.
Clinical pharmacology and therapeutics - 1 Dec 2004
Fukami Tatsuki, Nakajima Miki, Yoshida Ryoko, Tsuchiya Yuki, Fujiki Yuto, Katoh Miki, McLeod Howard L, Yokoi Tsuyoshi
Abstract excerpt
Cytochrome P450 (CYP) 2A6 is a major CYP responsible for the metabolism of nicotine and coumarin in humans. We identified a novel allele, designated CYP2A6*17 , which contains A51G (exon 1), C209T (intron 1), G1779A (exon 3), C4489T (intron 6), G5065A (V365M, exon 7), G5163A (intron 7), C5717T (exon 8), and A5825G (intron 8). We developed a genotyping method by polymerase chain reaction-restriction fragment...
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