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Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2017

Hosono Hiroki, Kumondai Masaki, Maekawa Masamitsu, Yamaguchi Hiroaki, Mano Nariyasu, Oda Akifumi, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

CYP2A6, a member of the cytochrome P450 (P450) family, is one of the enzymes responsible for the metabolism of therapeutic drugs and such tobacco components as nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and N-nitrosodiethylamine. Genetic polymorphisms in CYP2A6 are associated with individual variation in smoking behavior, drug toxicities, and the risk of developing several cancers. In this study,...

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PMID: 27974382
DOI: 10.1124/dmd.116.073494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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