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Article

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent.

Pharmacogenetics and genomics - 1 Jan 2008

Ho Man Ki, Mwenifumbo Jill C, Zhao Bin, Gillam Elizabeth M J, Tyndale Rachel F

Abstract excerpt

OBJECTIVES: CYP2A6 is the main enzyme involved in nicotine metabolism in humans. We have identified a novel allele, CYP2A6*23 (2161C>T, R203C), in individuals of Black-African descent and investigated its impact on enzyme activity and association with smoking status. METHODS: Wild-type and variant enzymes containing amino acid changes R203C (CYP2A6*23), R203S (CYP2A6*16) and V365M (CYP2A6*17) were expressed in...

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Identifiers

PMID: 18216723
DOI: 10.1097/FPC.0b013e3282f3606e
PMCID: PMC2910083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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