Article
Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.
Pharmacogenetics and genomics - 1 Feb 2014
Piliguian Mark, Zhu Andy Z X, Zhou Qian, Benowitz Neal L, Ahluwalia Jasjit S, Sanderson Cox Lisa, Tyndale Rachel F
Abstract excerpt
OBJECTIVE: Nicotine, the main addictive ingredient in tobacco, is metabolically inactivated to cotinine primarily by the hepatic enzyme CYP2A6. Considerable genetic variation in the CYP2A6 gene results in large variation in the rates of nicotine metabolism, which in turn alters smoking behaviours (e.g. amount of cigarettes smoked, risk for dependence and success in smoking cessation). The aim of this study was to...
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