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Article

Characterization of novel CYP2A6 polymorphic alleles (CYP2A618 and CYP2A619) that affect enzymatic activity.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2005

Fukami Tatsuki, Nakajima Miki, Higashi Eriko, Yamanaka Hiroyuki, Sakai Haruko, McLeod Howard L, Yokoi Tsuyoshi

Abstract excerpt

Genetic polymorphisms of CYP2A6 gene are known as a causal factor of the interindividual differences in nicotine metabolism. We found three novel CYP2A6 alleles. The CYP2A6(*)18A allele has a single nucleotide polymorphism (SNP) of A5668T (A1175T, Y392F) in exon 8. The CYP2A6(*)18B allele has synonymous SNPs of G51A (G51A), T5684C (T1191C), and T5702C (T1209C) in addition to A5668T (A1175T, Y392F). The...

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Identifiers

PMID: 15900015
DOI: 10.1124/dmd.105.004994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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