Article
LINE drive. retrotransposition and genome instability.
Cell - 9 Aug 2002
Kazazian Haig H, Goodier John L
Abstract excerpt
The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.
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