Retroelements in human disease.

doi:10.1016/j.gene.2013.01.008

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Article

Retroelements in human disease.

Gene - 15 Apr 2013

Kaer Kristel, Speek Mart

Abstract excerpt

Retroelements are an abundant class of noncoding DNAs present in about half of the human genome. Among them, L1, Alu and SVA are currently active. They "jump" by retrotransposition, shuffle genomic regions by 5' and 3' transduction, and promote or inhibit gene transcription by providing alternative promoters or generating antisense and/or regulatory noncoding RNAs. Recent data also suggest that retroelement...

Topics

Alternative Splicing
Gene Expression
Genetic Diseases, Inborn
Genetic Variation
Genome, Human
Humans
Mutation
Polyadenylation
Promoter Regions, Genetic
RNA Splice Sites
RNA Splicing
Retroelements
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 23333607
DOI: 10.1016/j.gene.2013.01.008

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