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Article

B7-independent inhibition of T cells by CTLA-4.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2005

Chikuma Shunsuke, Abbas Abul K, Bluestone Jeffrey A

Abstract excerpt

CTLA-4 is an inhibitory molecule that regulates T cell expansion and differentiation. CTLA-4 binding to B7-1/B7-2 is believed to be crucial for its inhibitory signal both by competing for CD28 binding to the same ligands and aggregating CTLA-4 to deliver negative signals. In this study, we demonstrate that B7 binding is not essential for CTLA-4 activity. CTLA-4 knockout T cells are hyperresponsive compared with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15972645
DOI: 10.4049/jimmunol.175.1.177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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B7-independent inhibition of T cells by CTLA-4.PMID 15972645Read ↗

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