Article
Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
Science (New York, N.Y.) - 5 Nov 1993
Freeman G J, Borriello F, Hodes R J, Reiser H, Hathcock K S, Laszlo G, McKnight A J, Kim J, Du L, Lombard D B
Abstract excerpt
B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was evaluated with B7-deficient mice. These mice had a 70 percent decrease in costimulation of the response to alloantigen. Despite lacking B7 expression, activated B cells from these mice bound CTLA-4 and GL1 monoclonal antibody,...
Topics
- Abatacept
- Animals
- Antigens, CD
- Antigens, Differentiation
- B-Lymphocytes
- B7-1 Antigen
- Base Sequence
- CTLA-4 Antigen
- Cell Line
- Immunoconjugates
- Interleukin-2