Article
Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
Science (New York, N.Y.) - 5 Nov 1993
Freeman G J, Borriello F, Hodes R J, Reiser H, Hathcock K S, Laszlo G, McKnight A J, Kim J, Du L, Lombard D B
Abstract excerpt
B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was evaluated with B7-deficient mice. These mice had a 70 percent decrease in costimulation of the response to alloantigen. Despite lacking B7 expression, activated B cells from these mice bound CTLA-4 and GL1 monoclonal antibody,...
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