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Article

Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2010

Ying Haiyan, Yang Lifen, Qiao Guilin, Li Zhenping, Zhang Li, Yin Fei, Xie Dong, Zhang Jian

Abstract excerpt

Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo....

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Source

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Identifiers

PMID: 20601598
DOI: 10.4049/jimmunol.0903369
PMCID: PMC2915549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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