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Article

The role of B7 costimulation in CD4/CD8 T cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2000

Yu X, Fournier S, Allison J P, Sharpe A H, Hodes R J

Abstract excerpt

The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice resulted in marked polyclonal peripheral T cell hyperplasia accompanied by skewing toward an increased proportion of CD8 single-positive cells and a decreased proportion of CD4 single-positive cells in thymus and more...

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Source

Identifiers

PMID: 10725709
DOI: 10.4049/jimmunol.164.7.3543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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