Article
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
Immunity - 1 Sept 2004
Pentcheva-Hoang Tsvetelina, Egen Jackson G, Wojnoonski Kathleen, Allison James P
Abstract excerpt
The reported affinity differences between CD28 and CTLA-4 binding to B7-1 and B7-2 may serve to selectively regulate CD28 and CTLA-4 function by differentially recruiting and/or stabilizing these molecules at the immunological synapse. Here we show that ligand binding is important for the accumulation of both CD28 and CTLA-4 at the synapse. While CD28 is recruited to the synapse in the absence of B7-1 and B7-2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.