Article
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells.
Immunity - 1 Dec 1997
Chambers C A, Sullivan T J, Allison J P
Abstract excerpt
CTLA-4-deficient animals develop a fatal lymphoproliferative disorder. The cellular mechanism(s) responsible for this phenotype have not been determined. Here, we show that there is a preferential expansion of CD4+ T cells in CTLA-4(-/-) mice, which results in a skewing of the CD4/CD8 T cell rati...
Topics
- Abatacept
- Animals
- Antigens, CD
- Antigens, Differentiation
- B-Lymphocytes
- B7-1 Antigen
- CD28 Antigens
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- CTLA-4 Antigen
- Cell Cycle
- Cell Division
- Gene Deletion
- Immunoconjugates
- Lymphocyte Depletion
- Lymphoid Tissue
- Lymphoproliferative Disorders