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Article

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).

The Journal of experimental medicine - 18 Jan 1999

Mandelbrot D A, McAdam A J, Sharpe A H

Abstract excerpt

The costimulatory molecules B7-1 and B7-2 regulate T lymphocyte activation by delivering activating signals through CD28 and inhibitory signals through cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). The importance of CTLA-4-mediated inhibition was demonstrated by the uncontrolled T cell activation and lymphoproliferative disease that develops in CTLA-4-deficient (-/-) mice. To examine the role of B7...

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Identifiers

PMID: 9892625
DOI: 10.1084/jem.189.2.435
PMCID: PMC2192978

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).PMID 9892625Read ↗

B7-independent inhibition of T cells by CTLA-4.Semantic proximity Read ↗

Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.Semantic proximity Read ↗

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells.Semantic proximity Read ↗

B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.Semantic proximity Read ↗

The role of B7 costimulation in CD4/CD8 T cell homeostasis.Semantic proximity Read ↗

B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo.Semantic proximity Read ↗

Differential T cell costimulatory requirements in CD28-deficient mice.Semantic proximity Read ↗

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.Semantic proximity Read ↗

Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.Semantic proximity Read ↗

Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.Semantic proximity Read ↗

The B7 family of immune-regulatory ligands.Semantic proximity Read ↗

CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion.Semantic proximity Read ↗

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