B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).

doi:10.1084/jem.189.2.435

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Article

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).

The Journal of experimental medicine - 18 Jan 1999

Mandelbrot D A, McAdam A J, Sharpe A H

Abstract excerpt

The costimulatory molecules B7-1 and B7-2 regulate T lymphocyte activation by delivering activating signals through CD28 and inhibitory signals through cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). The importance of CTLA-4-mediated inhibition was demonstrated by the uncontrolled T cell ac...

Topics

Abatacept
Animals
Antibodies
Antigens, CD
Antigens, Differentiation
B7-1 Antigen
B7-2 Antigen
CD28 Antigens
CD3 Complex
CTLA-4 Antigen
Cell Division
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Flow Cytometry

Immunoconjugates

Lymphoproliferative Disorders

Membrane Glycoproteins

Mice

Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 9892625
DOI: 10.1084/jem.189.2.435
PMCID: PMC2192978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9892625-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).PMID 9892625Read ↗

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