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Article

Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig.

PloS one - 1 Jan 2015

Rochman Yrina, Yukawa Masashi, Kartashov Andrey V, Barski Artem

Abstract excerpt

During activation, T cells integrate multiple signals from APCs and cytokine milieu. The blockade of these signals can have clinical benefits as exemplified by CTLA4-Ig, which blocks interaction of B7 co-stimulatory molecules on APCs with CD28 on T cells. Variants of CTLA4-Ig, abatacept and belatacept are FDA approved as immunosuppressive agents in arthritis and transplantation, yet murine studies suggested that...

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Share to Antigens, Surface
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

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Source

Open in PubMed Open full text

Identifiers

PMID: 25860138
DOI: 10.1371/journal.pone.0122198
PMCID: PMC4393265

Genes

CTLA4
CBLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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