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Article

Basic science for the clinician 55: CTLA-4.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases - 1 Apr 2012

Sigal Leonard H

Abstract excerpt

In physiological systems, for every "yang," there must be a "yin," for uncontrolled systems can run amok. This is the case for the T-cell compartment of the immune system, where activation must be modulated, dampened, and ultimately reversed; to not apply the brakes leads to dire consequences. In less than 20 years, CTLA-4 has emerged from being an orphan, next becoming a physiological star with ever-emerging...

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Share to Autoimmune Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Identifiers

PMID: 22456519
DOI: 10.1097/RHU.0b013e31824ea103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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