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Article

Deciphering the Spectrum of Mitochondrial DNA Mutations in Hepatocellular Carcinoma Using High-Throughput Sequencing.

Gene expression - 18 May 2018

Yu Chang, Wang Xuefeng, Huang Lifeng, Tong Ying, Chen Lili, Wu Hailong, Xia Qiang, Kong Xiaoni

Abstract excerpt

Accumulation of mitochondrial DNA (mtDNA) mutations has been proposed to contribute to the initiation and progression of tumors. By using high-throughput sequencing strategies, we measured 33 specimens including 11 hepatocellular carcinoma (HCC) tissues, 11 corresponding adjacent tissues, and 11 normal liver tissues. We identified 194 single nucleotide variants (SNVs; including insert and deletion) in 33 liver...

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Share to Carcinoma, Hepatocellular
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Liver Neoplasms

Share to Mitochondria, Liver

Share to Mutation

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 29463347
DOI: 10.3727/105221618X15185539348147
PMCID: PMC5954625

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