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Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis.

Cancer investigation - 1 Feb 2021

Alikhani Mehdi, Touati Eliette, Karimipoor Morteza, Vosough Massoud, Eybpoosh Sana, Mohammadi Marjan

Abstract excerpt

We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more...

Topics

DNA Copy Number Variations
DNA, Mitochondrial
Early Detection of Cancer
Gastrointestinal Neoplasms
Genetic Predisposition to Disease
Humans
Leukocytes, Mononuclear
Mitochondria

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33290105
DOI: 10.1080/07357907.2020.1857394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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