Article

Pneumococcal Evasion of Antibiotics via Metabolic Adaptation During Infection

2022-04-15

Abstract excerpt

<h4>ABSTRACT</h4> Streptococcus pneumoniae is a major human pathogen of global health concern, causing a range of mild to severe infections, including acute otitis media, pneumonia, sepsis, and meningitis. The rapid emergence of antibiotic resistance among S. pneumoniae isolates poses a serious public health problem worldwide. Resistant pneumococcal strains have rendered the mainstay treatment with beta-lactams,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2bceb51c-d36c-5db4-a287-c6a1e90c5a69
DOI: 10.1101/2022.04.14.488313

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pneumococcal Evasion of Antibiotics via Metabolic Adaptation During InfectionDOI 10.1101/2022.04.14.488313Read

A genome-wide atlas of antibiotic susceptibility targets and pathways to toleranceSemantic proximity Read

A genome-wide atlas of antibiotic susceptibility targets and pathways to toleranceSemantic proximity Read

The landscape of intrinsic and evolved fluoroquinolone resistance in <i>Acinetobacter baumannii</i> includes suppression of drug-induced prophage replicationSemantic proximity Read

Microscale insights into pneumococcal antibiotic mutant selection windows.Semantic proximity Read

Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolutionSemantic proximity Read

The Convergence of Antimicrobial Resistance and Virulence in <em>Streptococcus pneumoniae</em>: A Molecular and Clinical PerspectiveSemantic proximity Read

Divergent spontaneous antibiotic-resistance evolution confers reciprocal and exploitable collateral sensitivity effectsSemantic proximity Read

A functional genetic landscape of antibiotic sensitivity across the pneumococcal pangenome reveals conserved and lineage-specific vulnerabilitiesSemantic proximity Read

Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapySemantic proximity Read

Host Cell Oxidative Stress Promotes Intracellular Fluoroquinolone Persisters of Streptococcus pneumoniaeSemantic proximity Read

Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogensSemantic proximity Read

Fitness cost of antibiotic susceptibility during bacterial infection.Semantic proximity Read