Article
Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure.
eLife - 10 Dec 2013
Baker Stephen, Duy Pham Thanh, Nga Tran Vu Thieu, Dung Tran Thi Ngoc, Phat Voong Vinh, Chau Tran Thuy, Turner A Keith, Farrar Jeremy, Boni Maciej F
Abstract excerpt
Fluoroquinolones (FQ) are the recommended antimicrobial treatment for typhoid, a severe systemic infection caused by the bacterium Salmonella enterica serovar Typhi. FQ-resistance mutations in S. Typhi have become common, hindering treatment and control efforts. Using in vitro competition experiments, we assayed the fitness of eleven isogenic S. Typhi strains with resistance mutations in the FQ target genes, gyrA...
Topics
- Anti-Bacterial Agents
- Drug Resistance, Microbial
- Epistasis, Genetic
- Fluoroquinolones
- Microbial Sensitivity Tests
- Mutation
- Salmonella typhi