Article
Plasmidic qnrA3 Enhances Escherichia coli Fitness in Absence of Antibiotic Exposure
7 Sept 2011
Abstract excerpt
The widespread presence of plasmid-mediated quinolone resistance determinants, particularly qnr genes, has become a current issue. By protecting DNA-gyrase from quinolones, Qnr proteins confer a low level quinolone resistance that is not sufficient to explain their emergence. Since Qnr proteins were hypothesized to act as DNA-binding protein regulators, qnr genes could have emerged by providing a selective...
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