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Article

Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains.

Antimicrobial agents and chemotherapy - 1 Jul 2017

Popp Christina, Hampe Irene A I, Hertlein Tobias, Ohlsen Knut, Rogers P David, Morschhäuser Joachim

Abstract excerpt

The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis. Resistance is often caused by gain-of-function mutations in the transcription factors Mrr1 and Tac1, which result in constitutive overexpression of multidrug efflux pumps, and Upc2, which result in constitutive overexpression of ergosterol biosynthesis genes....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28461316
DOI: 10.1128/AAC.00584-17
PMCID: PMC5487674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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