Article
Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms.
Cancer - 15 Aug 2005
Zauber N Peter, Sabbath-Solitare Marlene, Marotta Stephen, Zauber Ann G, Foulkes William, Chan May, Turner Faye, Bishop D Timothy
Abstract excerpt
BACKGROUND: The authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented colorectal neoplasms. They further compared family and personal histories plus environmental exposures of the carriers and noncarriers of the I1307K mutation and examined...
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