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Article

Characterizing germline APC and MUTYH variants in Ashkenazi Jews compared to other individuals.

Familial cancer - 1 Apr 2021

Ukaegbu Chinedu, Levi Zohar, Fehlmann Tara D, Uno Hajime, Chittenden Anu, Inra Jennifer A, Grover Shilpa, Kastrinos Fay, Syngal Sapna, Yurgelun Matthew B

Abstract excerpt

Germline variants in the APC and MUTYH genes contribute to colorectal cancer (CRC) and adenoma risk, though may occur with varying frequencies in individuals of different ancestries. The aim of this study was to evaluate the prevalence of APC, monoallelic MUTYH and biallelic MUTYH germline variants in Ashkenazi Jewish (AJ) and Other Ancestry (OA) individuals with colorectal adenomas. We studied 7225 individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32743790
DOI: 10.1007/s10689-020-00198-x
PMCID: PMC7854904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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