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Article

A636P is associated with early-onset colon cancer in Ashkenazi Jews.

Journal of the American College of Surgeons - 1 Feb 2003

Guillem José G, Rapaport Beth S, Kirchhoff Tomas, Kolachana Prema, Nafa Khedoudja, Glogowski Emily, Finch Rob, Huang Helen, Foulkes William D, Markowitz Arnold, Ellis Nathan A, Offit Kenneth

Abstract excerpt

BACKGROUND: Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatous polyposis from mutations of APC, or hereditary nonpolyposis colorectal cancer, resulting from mutations of MSH2, MLH1, MSH6, or other genes. Previously, we described a rare founder mutation MSH2*1906C > G in Ashkenazi Jews that was found in 8 of 1,345 individuals (0.6%) of Ashkenazi descent with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Identifiers

PMID: 12595050
DOI: 10.1016/S1072-7515(02)01808-2

Genes

MSH2
APC
MLH1
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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A636P is associated with early-onset colon cancer in Ashkenazi Jews.PMID 12595050Read ↗

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