Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic instability of the APC I1307K allele in colorectal neoplasia.

Cancer research - 15 Sept 1998

Gryfe R, Di Nicola N, Gallinger S, Redston M

Abstract excerpt

The adenomatous polyposis coli (APC) gene is proposed to function as a gatekeeper of colorectal neoplasia. A germ-line variant of this gene, the APC I1307K allele, is present in approximately 6% of the Ashkenazi Jewish population. To assess the role in tumorigenesis of the variant (A)8 tract produced by this allele, we undertook a somatic mutation analysis of the region surrounding codon 1307 in colorectal tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Colorectal Neoplasms
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to APC gene

Share to Gene Deletion

Share to Germ-Line Mutation

Share to Microsatellite Repeats

Share to Point Mutation

Source

Identifiers

PMID: 9751605

Genes

APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic instability of the APC I1307K allele in colorectal neoplasia.PMID 9751605Read ↗

The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC I1307K variant using linkage disequilibrium.Semantic proximity Read ↗

Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract.Semantic proximity Read ↗

The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features.Semantic proximity Read ↗

The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews.Semantic proximity Read ↗

Position statement of the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) on APC I1307K and cancer risk.Semantic proximity Read ↗

The I1307K polymorphism of the APC gene in colorectal cancer.Semantic proximity Read ↗

Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia. Evidence for a founder effect.Semantic proximity Read ↗

Phenotypic characteristics associated with the APC gene I1307K mutation in Ashkenazi Jewish patients with colorectal polyps.Semantic proximity Read ↗

Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease.Semantic proximity Read ↗

APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews.Semantic proximity Read ↗

An update on APC I1307K homozygosity: observations from a large multigene panel testing cohort.Semantic proximity Read ↗

The APC I1307K allele conveys a significant increased risk for cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.