Article
Somatic instability of the APC I1307K allele in colorectal neoplasia.
Cancer research - 15 Sept 1998
Gryfe R, Di Nicola N, Gallinger S, Redston M
Abstract excerpt
The adenomatous polyposis coli (APC) gene is proposed to function as a gatekeeper of colorectal neoplasia. A germ-line variant of this gene, the APC I1307K allele, is present in approximately 6% of the Ashkenazi Jewish population. To assess the role in tumorigenesis of the variant (A)8 tract prod...
Topics
- Adenomatous Polyposis Coli
- Alleles
- Colorectal Neoplasms
- DNA Mutational Analysis
- Gene Deletion
- Genes, APC
- Germ-Line Mutation
- Humans
- Jews
- Microsatellite Repeats
- Point Mutation