Article
Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease.
Oncogene - 1 Jul 1999
Yin J, Harpaz N, Souza R F, Zou T, Kong D, Wang S, Leytin A L, Medalie N S, Smolinski K N, Abraham J M, Fleisher A S, Meltzer S J
Abstract excerpt
A germline sequence alteration at codon 1307 of the APC gene (I1307K) has been reported in 6-7% of the Ashkenazi Jewish population in the United States. This alteration is believed to predispose the APC gene to a secondary mutation at the same locus, resulting in an increased risk of colorectal carcinoma. There is an increased risk of colorectal carcinoma in patients with inflammatory bowel disease (IBD), a...
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