Article
High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx.
Oncogene - 1 Jun 1992
Maestro R, Dolcetti R, Gasparotto D, Doglioni C, Pelucchi S, Barzan L, Grandi E, Boiocchi M
Abstract excerpt
A series of 58 primary human squamous cell carcinomas of the larynx (LSCCs) was examined for the expression of the p53 tumor-suppressor gene by a combined immunohistochemical and molecular approach. About 60% of the cases displayed nuclear p53 overexpression as revealed by immunostaining with PAb...
Topics
- Antibodies, Monoclonal
- Base Sequence
- Blotting, Southern
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Exons
- Genes, p53
- Humans
- Immunohistochemistry
- Laryngeal Neoplasms
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- RNA, Neoplasm
- Restriction Mapping
- Smoking