Increased expression of mutant forms of p53 oncogene in primary lung cancer.

doi:10.1016/0140-6736(90)90801-b

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Article

Increased expression of mutant forms of p53 oncogene in primary lung cancer.

Lancet (London, England) - 24 Mar 1990

Iggo R, Gatter K, Bartek J, Lane D, Harris A L

Abstract excerpt

Primary lung cancer samples of the major histological types were examined for expression of the tumor suppressor gene p53 by immunohistochemistry. Abnormalities in p53 expression were found in 28 of 40 carcinomas, 14 of 17 squamous tumours showing abnormal p53 expression, whereas no expression of...

Topics

Adenocarcinoma
Alleles
Amino Acid Sequence
Autoradiography
Carcinoid Tumor
Carcinoma, Small Cell
Carcinoma, Squamous Cell
Chromosomes, Human, Pair 17
DNA, Neoplasm
Humans
Immunohistochemistry
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Oncogene Proteins

Phosphoproteins

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1969059
DOI: 10.1016/0140-6736(90)90801-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1969059-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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