Article
Overexpression of p53 protein in squamous cell carcinomas of head and neck without apparent gene mutations.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 1994
Xu L, Chen Y T, Huvos A G, Zlotolow I M, Rettig W J, Old L J, Garin-Chesa P
Abstract excerpt
Structural alterations of p53 and overexpression of the p53 protein are found in a large proportion of human cancers. In this study, we examined the frequency of p53 mutations and p53 overexpression in squamous cell carcinomas (SQCC) of head and neck. Expression of p53 was detected by immunochemistry (IHC) with monoclonal antibodies defining three distinct epitopes: PAb421 (species cross-reactive epitope on...
Topics
- Base Sequence
- Carcinoma, Squamous Cell
- DNA Probes
- Gene Expression
- Head and Neck Neoplasms
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Mutation
- Tumor Suppressor Protein p53