Article
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
The American journal of surgical pathology - 1 Mar 1993
Westra W H, Offerhaus G J, Goodman S N, Slebos R J, Polak M, Baas I O, Rodenhuis S, Hruban R H
Abstract excerpt
Mutations in the p53 tumor suppressor gene are frequently observed in primary lung adenocarcinomas, suggesting that these mutations are critical events in the malignant transformation of airway cells. These mutations are often associated with stabilization of the p53 gene product, resulting in th...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Codon
- Female
- Genes, p53
- Genes, ras
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Smoking
- Survival Analysis