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Article

Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2005

Redden David T, Shields Peter G, Epstein Leonard, Wileyto E Paul, Zakharkin Stanislav O, Allison David B, Lerman Caryn

Abstract excerpt

Review articles have focused attention on and cited possible reasons for the nonreplication of genetic association studies. Herein, we illustrate how one might work through these possible reasons to make a judgment about the most plausible reason(s) when faced with two or more studies which yield seemingly inconsistent results. In the first study, 342 treatment-seeking smokers were genotyped for the Val108Met...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15941945
DOI: 10.1158/1055-9965.EPI-04-0649

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results.PMID 15941945Read ↗

Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis.Semantic proximity Read ↗

Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.Semantic proximity Read ↗

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Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.Semantic proximity Read ↗

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Association of catechol-O-methyltransferase with smoking cessation in two independent studies of womenSemantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects.Semantic proximity Read ↗

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The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study.Semantic proximity Read ↗

Association of COMT Val108/158Met genotype with smoking cessation.Semantic proximity Read ↗

Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholismSemantic proximity Read ↗

Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls.Semantic proximity Read ↗

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