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Article

Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls.

Breast cancer research and treatment - 1 Jun 2010

Mao Chen, Wang Xi-Wen, Qiu Li-Xin, Liao Ru-Yan, Ding Hong, Chen Qing

Abstract excerpt

Epidemiological studies have evaluated the association between catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and breast cancer risk. However, the results remain conflicting rather than conclusive. In order to derive a more precise estimation of the relationship, we performed this meta-analysis. Systematic searches of the PubMed and Medline databases were performed. A total of 41 studies including...

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Source

Identifiers

PMID: 20464630
DOI: 10.1007/s10549-009-0650-4

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls.PMID 20464630Read ↗

Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in Asian population.Semantic proximity Read ↗

COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies.Semantic proximity Read ↗

Impact of Catechol-O-Methyltransferase Val 158Met (rs4680) Polymorphism on Breast Cancer Susceptibility in Asian PopulationSemantic proximity Read ↗

Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients.Semantic proximity Read ↗

Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,199 cases and 38,922 controls.Semantic proximity Read ↗

Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.Semantic proximity Read ↗

Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria.Semantic proximity Read ↗

Lack of associations of the COMT Val158Met polymorphism with risk of endometrial and ovarian cancer: a pooled analysis of case-control studies.Semantic proximity Read ↗

Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis.Semantic proximity Read ↗

[Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer].Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.Semantic proximity Read ↗

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