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Article

Association of COMT Val108/158Met genotype with smoking cessation.

Pharmacogenetics and genomics - 1 Feb 2008

Munafò Marcus R, Johnstone Elaine C, Guo Boliang, Murphy Michael F G, Aveyard Paul

Abstract excerpt

OBJECTIVES: We attempted to extend a previous finding of an association of COMT genotype with response to nicotine-replacement therapy (NRT), in a larger cohort of treatment-seeking smokers, with greater statistical power to detect possible moderating effects of sex. We also investigated the association of the COMT genotype with withdrawal and mood symptoms, to identify possible mediating mechanisms by which the...

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Source

Identifiers

PMID: 18192898
DOI: 10.1097/FPC.0b013e3282f44daa

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Association of COMT Val108/158Met genotype with smoking cessation.PMID 18192898Read ↗

Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.Semantic proximity Read ↗

Association of catechol-O-methyltransferase with smoking cessation in two independent studies of womenSemantic proximity Read ↗

Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects.Semantic proximity Read ↗

Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events.Semantic proximity Read ↗

Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women.Semantic proximity Read ↗

The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study.Semantic proximity Read ↗

Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis.Semantic proximity Read ↗

Are genetic variants of COMT associated with addiction?Semantic proximity Read ↗

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Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.Semantic proximity Read ↗

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