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Article

Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Dec 2012

Sun Hongqiang, Guo Song, Chen Dafang, Yang Fude, Zou Yizhuang, Di Xiaolan, Cao Yanjun, Kosten Thomas, Lu Lin, Zhang Xiang Yang

Abstract excerpt

Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers. We evaluated the efficacy and safety of sublingual nicotine tablets (SNT) for smoking cessation and the association of catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking...

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

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Source

Identifiers

PMID: 22695756
DOI: 10.1007/s00702-012-0841-8

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.PMID 22695756Read ↗

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Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.Semantic proximity Read ↗

Association of COMT Val108/158Met genotype with smoking cessation.Semantic proximity Read ↗

Association of catechol-O-methyltransferase with smoking cessation in two independent studies of womenSemantic proximity Read ↗

Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.Semantic proximity Read ↗

The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study.Semantic proximity Read ↗

Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects.Semantic proximity Read ↗

Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events.Semantic proximity Read ↗

Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence.Semantic proximity Read ↗

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