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Article

The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells.

Journal of cell science - 1 Jan 2002

Gasparian Alexander V, Yao Ya Juan, Kowalczyk Dariusz, Lyakh Ludmila A, Karseladze Apollon, Slaga Thomas J, Budunova Irina V

Abstract excerpt

Rel/NF-kappaB transcription factors are implicated in the control of cell proliferation, apoptosis and transformation. The key to NF-kappaB regulation is the inhibitory IkappaB proteins. During response to diverse stimuli, IkappaBs are rapidly phosphorylated by IkappaB kinases (IKKs), ubiquitinated and undergo degradation. We have investigated the expression and function of NF-kappaB, IkappaB inhibitors and IKKs...

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Identifiers

PMID: 11801732
DOI: 10.1242/jcs.115.1.141

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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