Article
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Molecular and cellular neurosciences - 1 Sept 2006
Schultz Christian, König Hans-Georg, Del Turco Domenico, Politi Chrisoula, Eckert Gunter P, Ghebremedhin Estifanos, Prehn Jochen H M, Kögel Donat, Deller Thomas
Abstract excerpt
Phosphorylation of the inhibitory protein IkappaBalpha by the activated IkappaB kinase (IKK) is a crucial step in the activation of the transcription factor NF-kappaB. In neurons of the mammalian central nervous system, constitutive activation of NF-kappaB has been previously documented. The cellular compartments involved in this activation have not yet been fully identified. Here we document a striking...
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