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Article

Different outcomes of unliganded and liganded estrogen receptor-alpha on neurite outgrowth in PC12 cells.

Endocrinology - 1 Jan 2009

Mérot Yohann, Ferrière François, Gailhouste Luc, Huet Guillaume, Percevault Frédéric, Saligaut Christian, Flouriot Gilles

Abstract excerpt

A precise description of the mechanisms by which estrogen receptor-alpha (ERalpha) exerts its influences on cellular growth and differentiation is still pending. Here, we report that the differentiation of PC12 cells is profoundly affected by ERalpha. Importantly, depending upon its binding to 17beta-estradiol (17betaE2), ERalpha is found to exert different effects on pathways involved in nerve growth factor...

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Source

Identifiers

PMID: 18772239
DOI: 10.1210/en.2008-0449

Genes

NGF
VGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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