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Article

Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2005

Yin Ophelia Q P, Shi X J, Tomlinson B, Chow Moses S S

Abstract excerpt

Loratadine is known to be a substrate for both CYP3A4 and CYP2D6 based on a previous in vitro study. In view of the large interindividual variability in loratadine pharmacokinetics and the greater genetically determined variability of CYP2D6 activity than of CYP3A4 in vivo, we hypothesized that CYP2D6 polymorphisms may contribute to the pharmacokinetic variability of loratadine. The purpose of this study was to...

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PMID: 15932952
DOI: 10.1124/dmd.105.005025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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